Col1a1^{tm15(CAG-Fgfr1*)Nki}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm15(CAG-Fgfr1*)Nki}
• Name: collagen, type I, alpha 1; targeted mutation 15, The Netherlands Cancer Institute
• MGI ID: MGI:6158304
• Synonyms: LSL-Fgfr1^K656E
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm15(CAG-Fgfr1*)Nki} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236715
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: FVB

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: RMCE introduced into the 3' UTR the targeting construct Fgfr1-frt-invCAG that contains and inverted CAG promoter, the Fgfr1 gene with the mutation resulting in the amino acid substitution of glutamic acid for lysin at position 656, an IRES sequence and a YFP reporter gene. Cre-mediated recombination is required to achieve expression. (J:236716)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 166 strains or lines available

References

• Original: J:236715 Ferone G, et al., SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin. Cancer Cell. 2016 Oct 10;30(4):519-532
• All: 2 reference(s)