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Spontaneous Allele Detail
Symbol: Cd5b
Name: CD5 antigen; b variant
MGI ID: MGI:6157523
Synonyms: CD5.2, Ly-1.2
Gene: Cd5  Location: Chr19:10695471-10716390 bp, - strand  Genetic Position: Chr19, 7.16 cM
Strain of Origin:  multiple strains
Allele Type:    Spontaneous (Not Applicable)
Mutation:    Undefined
Mutation detailsThis variant is found in many inbred strains including C57BL/6J, C58/J, AKR/J, SJL/J, SWR. Sequence analysis shows that relative to the a variant of C3H/HeJ the b variant has point mutations that result in isoleucine instead of valine at amino acid 9, glutamine instead of leucine at amino acid 52, and phenylalanine instead of isoleucine at amino acid 71, all within the amino terminal scavenger receptor cysteine-rich D1 domain, in addition to 7 silent point mutations. (J:8546, J:40410)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Cd5 Mutation:  26 strains or lines available
Original:  J:5073 Boyse EA, et al., Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(19):175-93
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory