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Cd5a
Spontaneous Allele Detail
Nomenclature
Symbol: Cd5a
Name: CD5 antigen; a variant
MGI ID: MGI:6157436
Synonyms: CD5.1, Ly-1.1
Gene: Cd5  Location: Chr19:10718107-10739026 bp, - strand  Genetic Position: Chr19, 7.16 cM
Mutation
origin
Strain of Origin:  multiple strains
Mutation
description
Allele Type:    Spontaneous (Not Applicable)
Mutation:    Nucleotide substitutions
 
Mutation detailsSequence analysis of C3H/HeJ showed that this polymorphic variant has point mutations relative to the b variant that result in valine instead of isoleucine at amino acid 9, leucine instead of glutamine at amino acid 52, and isoleucine instead of phenylalanine at amino acid 71, all within the amino terminal scavenger receptor cysteine-rich D1 domain, in addition to 7 silent point mutations. This allele is found in many inbred strains including CBA/J, C3H and DBA substrains. (J:8546, J:40410)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Cd5 Mutation:  26 strains or lines available
References
Original:  J:5073 Boyse EA, et al., Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(19):175-93
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory