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Spontaneous Allele Detail
Symbol: Ogg1m1
Name: 8-oxoguanine DNA-glycosylase 1; mutation 1
MGI ID: MGI:6157073
Synonyms: OGG1-R336H
Gene: Ogg1  Location: Chr6:113303871-113311838 bp, + strand  Genetic Position: Chr6, 52.75 cM, cytoband E-F1
Strain of Origin:  various
Allele Type:    Spontaneous (Not Applicable)
Mutation:    Single point mutation
Mutation detailsA G-to-A change at the fifty-ninth nucleotide in exon 7 resulted in a substitution of arginine with histidine at position 336 (p.R336H) in a putative nuclear localization signal. The mutation led to disruption of the nuclear localization of the enzyme, although the activity remained normal. (J:59724)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ogg1 Mutation:  23 strains or lines available
Original:  J:59724 Choi JY, et al., Thermolabile 8-hydroxyguanine DNA glycosylase with low activity in senescence-accelerated mice due to a single-base mutation. Free Radic Biol Med. 1999 Oct;27(7-8):848-54
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory