Tg(Myh6-PPARD)2Dpk
Transgene Detail

Summary

• Symbol: Tg(Myh6-PPARD)2Dpk
• Name: transgene insertion 2, Daniel P Kelly
• MGI ID: MGI:6157071
• Synonyms: MHC-PPARbeta/delta-LE, MHC-PPARbeta/delta (low expression)
• Transgene: Tg(Myh6-PPARD)2Dpk Location: unknown
• Alliance: Tg(Myh6-PPARD)2Dpk page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA/J)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-PPARD)2Dpk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PPARD (5467)

  Ppard

  (MGI:101884)

• Mutation details: The transgene contains a 1.0-kb human peroxisome proliferator activated receptor delta (PPARD) cDNA under control of the promoter of the myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6) gene. Expression of the transgene was detected only in the heart. Northern blot analysis of RNA isolated from hearts of 8-week-old mice of this transgenic line revealed transgene-derived mRNA levels ~20-fold the endogenous levels. (J:130750)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:130750 Burkart EM, et al., Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart. J Clin Invest. 2007 Dec;117(12):3930-9
• All: 1 reference(s)