Mdm4^tm1.1Chj
Targeted Allele Detail

Summary

• Symbol: Mdm4^tm1.1Chj
• Name: MDM4 regulator of p53; targeted mutation 1.1, Jiandong Chen
• MGI ID: MGI:6156967
• Synonyms: MDMX^SG
• Gene: Mdm4 Location: Chr1:132913843-132958325 bp, - strand Genetic Position: Chr1, 57.75 cM, cytoband G-G
• Alliance: Mdm4^tm1.1Chj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261424
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac and C57BL/6

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed neo cassette was inserted in intron 7 and W201S/W202G mutations were inserted in exon 8 via homologous recombination. Cre mediated recombination removed the neo cassette. This mutation disrupts intramolecular interactions and binding to CSNK1A1 and acidic domain-TRP53 core binding. (J:261424)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mdm4 Mutation: 190 strains or lines available

References

• Original: J:261424 Huang Q, et al., MDMX acidic domain inhibits p53 DNA binding in vivo and regulates tumorigenesis. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3368-E3377
• All: 2 reference(s)