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Auts2tm1Mhos
Targeted Allele Detail
Nomenclature
Symbol: Auts2tm1Mhos
Name: autism susceptibility candidate 2; targeted mutation 1, Mikio Hoshino
MGI ID: MGI:6156948
Synonyms: Auts2neo
Gene: Auts2  Location: Chr5:131437333-132543220 bp, - strand  Genetic Position: Chr5, 70.66 cM, cytoband G1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:243531
Parent Cell Line:  RENKA (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 8 and a loxP site and a FRT-flanked neomycin cassette were inserted downstream of exon 8 in opposite orientation. Immunohistochemistry indicates that both the full-length and shorter splicing variant (variant 1 with transcriptional start site in exon 7) proteins are almost completely eliminated in the brain of homozygotes. (J:243531)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Auts2 Mutation:  9 strains or lines available
References
Original:  J:243531 Hori K, et al., Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis. Cell Rep. 2014 Dec 24;9(6):2166-79
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory