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Phrf1em1(IMPC)Tcp
Endonuclease-mediated Allele Detail
Summary
Symbol: Phrf1em1(IMPC)Tcp
Name: PHD and ring finger domains 1; endonuclease-mediated mutation 1, The Centre for Phenogenomics
MGI ID: MGI:6156548
Gene: Phrf1  Location: Chr7:140808697-140842663 bp, + strand  Genetic Position: Chr7, 86.53 cM
Alliance: Phrf1em1(IMPC)Tcp page
IMPC: Phrf1 gene page
Mutation
origin
Strain of Origin:  C57BL/6NCrl
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele from project TCPR1025 was generated at The Centre for Phenogenomics by electroporating Cas9 ribonucleoprotein complexes with single guide RNAs having with spacer sequences of GCCTGAGGACCCCATAACAT and ACATTCCATGTGGTACCTAT targeting the 5' side and CCTGCCATATGACCATGCTA and AGCGTAGGTGAGTCTATTGA targeting the 3' side of a critical region. This resulted in a 826-bp deletion from Chr7:141246719 to 141247544 (GRCm38). (J:237616)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Phrf1 Mutation:  73 strains or lines available
References
Original:  J:237616 MGI and IMPC, MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). MGI Direct Data Submission. 2017-8;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory