Icos^tm2.1Wks
Targeted Allele Detail

Summary

• Symbol: Icos^tm2.1Wks
• Name: inducible T cell co-stimulator; targeted mutation 2.1, Woong-Kyung Suh
• MGI ID: MGI:6156417
• Synonyms: ICOS^fl
• Gene: Icos Location: Chr1:61017086-61039479 bp, + strand Genetic Position: Chr1, 30.6 cM
• Alliance: Icos^tm2.1Wks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261486
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a second loxP site and a FRT-flanked neomycin resistance cassette were inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette leaving exons 2-3 floxed. (J:261486)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Icos Mutation: 30 strains or lines available

References

• Original: J:261486 Panneton V, et al., ICOS Signaling Controls Induction and Maintenance of Collagen-Induced Arthritis. J Immunol. 2018 May 1;200(9):3067-3076
• All: 4 reference(s)