Ern1^tm1.1Ccah
Targeted Allele Detail

Summary

• Symbol: Ern1^tm1.1Ccah
• Name: endoplasmic reticulum to nucleus signalling 1; targeted mutation 1.1, Chih-Chi Andrew Hu
• MGI ID: MGI:6156143
• Synonyms: S729A
• Gene: Ern1 Location: Chr11:106285476-106378678 bp, - strand Genetic Position: Chr11, 69.14 cM, cytoband E1
• Alliance: Ern1^tm1.1Ccah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261443
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A serine to alanine change at amino acid 729 (S729A) was introduced in exon 17 and a FRT-flanked neomycin selection cassette was inserted downstream of exon 17. Flp-mediated recombination removed the selection cassette. (J:261443)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ern1 Mutation: 58 strains or lines available

References

• Original: J:261443 Tang CA, et al., Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization. J Cell Biol. 2018 May 7;217(5):1739-1755
• All: 3 reference(s)