Nrg3^tm1.1Line
Targeted Allele Detail

Summary

• Symbol: Nrg3^tm1.1Line
• Name: neuregulin 3; targeted mutation 1.1, Lin Mei
• MGI ID: MGI:6155667
• Synonyms: Nrg3^f
• Gene: Nrg3 Location: Chr14:38090909-39195045 bp, - strand Genetic Position: Chr14, 22.18 cM, cytoband B
• Alliance: Nrg3^tm1.1Line page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260594
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:260594)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrg3 Mutation: 56 strains or lines available

References

• Original: J:260594 Wang YN, et al., Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2508-2513
• All: 1 reference(s)