Mastl^tm1.2Kald
Targeted Allele Detail

Summary

• Symbol: Mastl^tm1.2Kald
• Name: microtubule associated serine/threonine kinase-like; targeted mutation 1.2, Philip Kaldis
• MGI ID: MGI:6155624
• Synonyms: Mastl^NULL
• Gene: Mastl Location: Chr2:23006549-23046036 bp, - strand Genetic Position: Chr2, 15.23 cM
• Alliance: Mastl^tm1.2Kald page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235649
• Parent Cell Line: S1B6 (ES Cell)
• Strain of Origin: 129S1/SvImJ or C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination deleted exon 4 in the germline resulting in a frameshift. (J:235649)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mastl Mutation: 36 strains or lines available

References

• Original: J:235649 Diril MK, et al., Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint. PLoS Genet. 2016 Sep;12(9):e1006310
• All: 1 reference(s)