Kat2b^tm1.1Jsan
Targeted Allele Detail

Summary

• Symbol: Kat2b^tm1.1Jsan
• Name: K(lysine) acetyltransferase 2B; targeted mutation 1.1, Jean-Sebastien Annicotte
• MGI ID: MGI:6155606
• Synonyms: Kat2b^L2
• Gene: Kat2b Location: Chr17:53873889-53979748 bp, + strand Genetic Position: Chr17, 27.86 cM
• Alliance: Kat2b^tm1.1Jsan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235385
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 11 and a loxP site, FRT site, neomycin selection cassette, loxP site and FRT site were inserted downstream of exon 11. Flp-mediated recombination removed the selection cassette, leaving exon 11 floxed. (J:235385)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat2b Mutation: 152 strains or lines available

References

• Original: J:235385 Rabhi N, et al., KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response. Cell Rep. 2016 May 3;15(5):1051-61
• All: 1 reference(s)