Pml^tm2.1Ppp
Targeted Allele Detail

Summary

• Symbol: Pml^tm2.1Ppp
• Name: promyelocytic leukemia; targeted mutation 2.1, Pier P Pandolfi
• MGI ID: MGI:6155604
• Synonyms: Pml^flox
• Gene: Pml Location: Chr9:58125359-58157069 bp, - strand Genetic Position: Chr9, 31.63 cM
• Alliance: Pml^tm2.1Ppp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260988
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:260988)

Tumor Data

List all tumor models in MMHCdb carrying Pml^tm2.1Ppp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pml Mutation: 91 strains or lines available

References

• Original: J:260988 Chen M, et al., An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. Nat Genet. 2018 Feb;50(2):206-218
• All: 2 reference(s)