Lcn2^tm1.1Bga
Targeted Allele Detail

Summary

• Symbol: Lcn2^tm1.1Bga
• Name: lipocalin 2; targeted mutation 1.1, Bin Gao
• MGI ID: MGI:6155602
• Synonyms: Lcn2^flox
• Gene: Lcn2 Location: Chr2:32274649-32277751 bp, - strand Genetic Position: Chr2, 22.09 cM, cytoband A3
• Alliance: Lcn2^tm1.1Bga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261336
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and FRT-flanked neomycin selection cassette were inserted upstream of exon 2 and a second loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the selection cassette leaving exons 2-6 floxed. (J:261336)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lcn2 Mutation: 30 strains or lines available

References

• Original: J:261336 Xu MJ, et al., Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3. Hepatology. 2015 Feb;61(2):692-702
• All: 3 reference(s)