Lgr4^tm1.1Myliu
Targeted Allele Detail

Summary

• Symbol: Lgr4^tm1.1Myliu
• Name: leucine-rich repeat-containing G protein-coupled receptor 4; targeted mutation 1.1, Mingyao Liu
• MGI ID: MGI:6155023
• Synonyms: Lgr4^fl
• Gene: Lgr4 Location: Chr2:109747992-109844602 bp, + strand Genetic Position: Chr2, 56.65 cM
• Alliance: Lgr4^tm1.1Myliu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235185
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 14 and a FRT-flanked neomycin selection cassette and a second loxP site were inserted downstream of exon 17. Flp-mediated recombination removed the selection cassette, leaving exons 14-17 floxed. (J:235185)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lgr4 Mutation: 92 strains or lines available

References

• Original: J:235185 Luo J, et al., LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption. Nat Med. 2016 May;22(5):539-46
• All: 3 reference(s)