Vtn^tm1.1Kekk
Targeted Allele Detail

Summary

• Symbol: Vtn^tm1.1Kekk
• Name: vitronectin; targeted mutation 1.1, Kevin K Kim
• MGI ID: MGI:6155017
• Synonyms: VTN^RGE
• Gene: Vtn Location: Chr11:78389946-78393151 bp, + strand Genetic Position: Chr11, 46.74 cM
• Alliance: Vtn^tm1.1Kekk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235162
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Single point mutation
• Mutation details: Exon 3 was replaced with one in which the RGD sequence was mutated to a nonintegrin-binding RGE sequence (CGGGGGGAC to CGGGGGGAG) and a FRT-flanked neomycin resistance cassette was inserted downstream of exon 6. Flp-mediated recombination removed the selection cassette. Western blot analysis confirmed expression of the mutated protein. (J:235162)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vtn Mutation: 23 strains or lines available

References

• Original: J:235162 Wheaton AK, et al., The vitronectin RGD motif regulates TGF-beta-induced alveolar epithelial cell apoptosis. Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1206-17
• All: 2 reference(s)