Nrp1^em1Cruh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nrp1^em1Cruh
• Name: neuropilin 1; endonuclease-mediated mutation 1, Christiana Ruhrberg
• MGI ID: MGI:6155008
• Synonyms: Nrp1^D320K
• Gene: Nrp1 Location: Chr8:129085085-129229844 bp, + strand Genetic Position: Chr8, 75.78 cM, cytoband E
• Alliance: Nrp1^em1Cruh page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology introduced a lysine to aspartate substitution at amino acid 320 (D320K) which is predicted to abrogate VEGF164 binding to NRP1. (J:241872)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nrp1 Mutation: 81 strains or lines available

References

• Original: J:241872 Fantin A, et al., VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation. J Exp Med. 2017 Apr 03;214(4):1049-1064
• All: 1 reference(s)