Pax2^tm1.2Akio
Targeted Allele Detail

Summary

• Symbol: Pax2^tm1.2Akio
• Name: paired box 2; targeted mutation 1.2, Akio Kobayashi
• MGI ID: MGI:6154955
• Synonyms: Pax2^del
• Gene: Pax2 Location: Chr19:44744484-44826310 bp, + strand Genetic Position: Chr19, 38.09 cM
• Alliance: Pax2^tm1.2Akio page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241850
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was flanked by loxP sites and an FRT-flanked PGK-neomycin selection cassette was introduced following the second loxP site. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2 causing a frame-shift mutation with a premature translational termination producing a transcript encoding only the first 14 amino acids. (J:241850)

Expression

In Mice Carrying this Mutation:

78 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax2 Mutation: 44 strains or lines available

References

• Original: J:241850 Naiman N, et al., Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 May 22;41(4):349-365.e3
• All: 1 reference(s)