Erbb4^tm1.1Line
Targeted Allele Detail

Summary

• Symbol: Erbb4^tm1.1Line
• Name: erb-b2 receptor tyrosine kinase 4; targeted mutation 1.1, Lin Mei
• MGI ID: MGI:6154872
• Synonyms: T796G
• Gene: Erbb4 Location: Chr1:68071345-69147218 bp, - strand Genetic Position: Chr1, 33.8 cM
• Alliance: Erbb4^tm1.1Line page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261265
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac and C57BL/6J

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A floxed neo cassette and T796G mutation in exon 20 were inserted via homologous recombination. Cre-mediated recombination removed the neo cassette. This mutation enlarges the ATP binding pocket and allows specific inhibition by 4-amino-1-tert-butyl-3-(1'-naphthylmethyl)pyrazolo[3,4-d]pyrimidine. (J:261265)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb4 Mutation: 87 strains or lines available

References

• Original: J:261265 Tan Z, et al., Dynamic ErbB4 Activity in Hippocampal-Prefrontal Synchrony and Top-Down Attention in Rodents. Neuron. 2018 Apr 18;98(2):380-393.e4
• All: 2 reference(s)