Grn^tm1Kano
Targeted Allele Detail

Summary

• Symbol: Grn^tm1Kano
• Name: granulin; targeted mutation 1, Masanobu Kano
• MGI ID: MGI:6154856
• Synonyms: Grn^flox
• Gene: Grn Location: Chr11:102321333-102327635 bp, + strand Genetic Position: Chr11, 66.29 cM
• Alliance: Grn^tm1Kano page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261277
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2, an FRT flanked neo cassette was inserted downstream of exon 2 and a loxP site was inserted downstream of exon 4 via homologous recombination. (J:261277)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grn Mutation: 51 strains or lines available

References

• Original: J:261277 Uesaka N, et al., Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum. Neuron. 2018 Feb 21;97(4):796-805.e5
• All: 1 reference(s)