Cd82^tm1.2Sbae
Targeted Allele Detail

Summary

• Symbol: Cd82^tm1.2Sbae
• Name: CD82 antigen; targeted mutation 1.2, Sung Hee Baek
• MGI ID: MGI:6154700
• Gene: Cd82 Location: Chr2:93249447-93293295 bp, - strand Genetic Position: Chr2, 51.62 cM
• Alliance: Cd82^tm1.2Sbae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234812
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A FRT-flanked neomycin cassette containing a loxP sequence was inserted at the 3' end of exon 6, and a single loxP site was inserted at the 5' end of exon 5. Flp-mediated recombination removed the neomycin cassette. Cre-mediated recombination in the germline deleted exons 5 and 6. (J:234812)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd82 Mutation: 16 strains or lines available

References

• Original: J:234812 Hur J, et al., CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages. Cell Stem Cell. 2016 Apr 7;18(4):508-21
• All: 1 reference(s)