Kcnj11^tm1.1Wco
Targeted Allele Detail

Summary

• Symbol: Kcnj11^tm1.1Wco
• Name: potassium inwardly rectifying channel, subfamily J, member 11; targeted mutation 1.1, William A Coetzee
• MGI ID: MGI:6154674
• Synonyms: Kir6.2^Flx
• Gene: Kcnj11 Location: Chr7:45746545-45750215 bp, - strand Genetic Position: Chr7, 29.66 cM
• Alliance: Kcnj11^tm1.1Wco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234808
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and a FRT-flanked neo cassette were inserted on the 3' side of exon 1 and the second loxP site was inserted approximately 1.7 kb 5' of the start of exon 1. Flp-mediated recombination removed the neo cassette, leaving 3,198 bp, including exon 1 and about 1.7 kb of upstream sequence, floxed. (J:234808)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnj11 Mutation: 33 strains or lines available

References

• Original: J:234808 Yang HQ, et al., Plasticity of sarcolemmal KATP channel surface expression: relevance during ischemia and ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1558-66
• All: 1 reference(s)