Birc2^tm1.1Pme
Targeted Allele Detail

Summary

• Symbol: Birc2^tm1.1Pme
• Name: baculoviral IAP repeat-containing 2; targeted mutation 1.1, Pascal Meier
• MGI ID: MGI:6154624
• Synonyms: cIAP1^UBAmut
• Gene: Birc2 Location: Chr9:7818228-7837065 bp, - strand Genetic Position: Chr9, 2.46 cM, cytoband A1
• Alliance: Birc2^tm1.1Pme page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260804
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A floxed mini-gene containing exons 4-7 and a BGH poly-A signal were inserted upstream of exon 4, M396A and F398A mutations were inserted in exon 4, and an F3 site flanked pgk-hygro cassette was inserted in upstream of the mutated exon 4 via homologous recombination. Targeting was done in ES cells carrying Birc3^tm1Rbr . Flp and cre mediated recombination removed the pgk-hygro cassette and floxed mini-gene. (J:260804)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Birc2 Mutation: 31 strains or lines available

References

• Original: J:260804 Annibaldi A, et al., Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2. Mol Cell. 2018 Feb 15;69(4):566-580.e5
• All: 1 reference(s)