Traf3^tm1.1Holi
Targeted Allele Detail

Summary

• Symbol: Traf3^tm1.1Holi
• Name: TNF receptor-associated factor 3; targeted mutation 1.1, Hongliang Li
• MGI ID: MGI:6153854
• Synonyms: TRAF3^flox
• Gene: Traf3 Location: Chr12:111132804-111233587 bp, + strand Genetic Position: Chr12, 60.94 cM, cytoband F
• Alliance: Traf3^tm1.1Holi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260823
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a FRT-flanked PGK-EM7-Neo selection cassette and a second loxP site were inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette leaving exon 3 floxed. (J:260823)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Traf3 Mutation: 41 strains or lines available

References

• Original: J:260823 Jiang X, et al., Tumor necrosis factor receptor-associated factor 3 is a positive regulator of pathological cardiac hypertrophy. Hypertension. 2015 Aug;66(2):356-67
• All: 2 reference(s)