Rnf135^tm1Tsse
Targeted Allele Detail

Summary

• Symbol: Rnf135^tm1Tsse
• Name: ring finger protein 135; targeted mutation 1, Tsukasa Seya
• MGI ID: MGI:6153155
• Synonyms: Riplet KO
• Gene: Rnf135 Location: Chr11:80074677-80090583 bp, + strand Genetic Position: Chr11, 47.59 cM, cytoband B5
• Alliance: Rnf135^tm1Tsse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260659
• Parent Cell Line: EGR-05 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 2 and 3 were replaced with a PGK-neo cassette. (J:260659)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf135 Mutation: 40 strains or lines available

References

• Original: J:260659 Oshiumi H, et al., The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection. Cell Host Microbe. 2010 Dec 16;8(6):496-509
• All: 3 reference(s)