Tsc2^tm1.1Mwka
Targeted Allele Detail

Summary

• Symbol: Tsc2^tm1.1Mwka
• Name: TSC complex subunit 2; targeted mutation 1.1, Mari Wataya-Kaneda
• MGI ID: MGI:6151119
• Synonyms: Tsc2:loxP
• Gene: Tsc2 Location: Chr17:24814790-24851604 bp, - strand Genetic Position: Chr17, 12.41 cM
• Alliance: Tsc2^tm1.1Mwka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259390
• Parent Cell Line: KY1.1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele contains loxP sites flanking exons 3, 4 and 5. A frt-flanked neomycin selection cassette was removed from the second intron by crossing with mice expressing FLP recombinase in the germline, leaving a single frt site downstream of the first loxP site. (J:259390)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tsc2 Mutation: 77 strains or lines available

References

• Original: J:259390 Yang F, et al., Uncoupling of ER/Mitochondrial Oxidative Stress in mTORC1 Hyperactivation-Associated Skin Hypopigmentation. J Invest Dermatol. 2018 Mar;138(3):669-678
• All: 2 reference(s)