Cflar^m1
Spontaneous Allele Detail

Summary

• Symbol: Cflar^m1
• Name: CASP8 and FADD-like apoptosis regulator; mutation 1
• MGI ID: MGI:6150920
• Synonyms: Cflar^MSM
• Gene: Cflar Location: Chr1:58750667-58798043 bp, + strand Genetic Position: Chr1, 29.16 cM
• Alliance: Cflar^m1 page

Mutation origin

• Strain of Origin: multiple strains

Mutation description

• Allele Type: Spontaneous (Modified isoform(s))
• Mutation: Insertion
• Mutation details: This 21 bp insertion in the 3' UTR of exon 5 contains a putative binding site for the U2 snRNP that alters splicing. The insertion has been identified in MOLF/Ei, PWK/Ei and SPRETUS/Ei but not Mus musculus domesticus strains such as C57BL/6 or in CAST/EI. Hepatocytes from Mus musculus molossinus primarily express the long isoform whereas C57BL/6 hepatocytes express the short isoform. (J:244556)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cflar Mutation: 32 strains or lines available

References

• Original: J:244556 Ram DR, et al., Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo. Proc Natl Acad Sci U S A. 2016 Feb 09;113(6):1606-11
• All: 1 reference(s)