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Rnf146tm1.1Rtpl
Targeted Allele Detail
Nomenclature
Symbol: Rnf146tm1.1Rtpl
Name: ring finger protein 146; targeted mutation 1.1, Robert Rottapel
MGI ID: MGI:6150887
Synonyms: Rnf146fl
Gene: Rnf146  Location: Chr10:29344176-29362442 bp, - strand  Genetic Position: Chr10, 16.6 cM, cytoband A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:243612
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted into intron 3. A second loxP site was inserted into the 3' UTR of exon 4. Flp-mediated recombination removed the FRT-flanked selection cassette inserted into the 3' UTR. (J:243612)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rnf146 Mutation:  14 strains or lines available
References
Original:  J:243612 Matsumoto Y, et al., RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146. J Clin Invest. 2017 Apr 03;127(4):1303-1315
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory