Ptpn22^tm1.2Rza
Targeted Allele Detail

Summary

• Symbol: Ptpn22^tm1.2Rza
• Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid); targeted mutation 1.2, Rose Zamoyska
• MGI ID: MGI:6150845
• Gene: Ptpn22 Location: Chr3:103767111-103819563 bp, + strand Genetic Position: Chr3, 45.52 cM, cytoband F3
• Alliance: Ptpn22^tm1.2Rza page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259087
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP aite was inserted 5' to exon 1 and a loxP-flanked neomycin selection cassette was inserted 3' to exon 1. Cre-mediated recombination removed both exon 1 and the loxP-flanked neomycin selection cassette. (J:259087)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn22 Mutation: 50 strains or lines available

References

• Original: J:259087 Brownlie RJ, et al., Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function. Sci Signal. 2012 Nov 27;5(252):ra87
• All: 8 reference(s)