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Arhgap29tm1Murr
Targeted Allele Detail
Nomenclature
Symbol: Arhgap29tm1Murr
Name: Rho GTPase activating protein 29; tarageted mutation 1, Stephen Murray
MGI ID: MGI:6150826
Synonyms: K326X
Gene: Arhgap29  Location: Chr3:121953113-122016677 bp, + strand  Genetic Position: Chr3, 52.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:257248
Parent Cell Line:  JM8 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Humanized sequence, Null/knockout)
Mutations:    Other, Single point mutation
 
Mutation detailsAn A to T point substitution at base 1184 in exon 11 introduces a lysine to stop codon mutation at amino acid 325 (K325X), which is amino acid 326 in human. An FRT-flanked neomycin selection cassette was also introduced 3-prime of exon 11. (J:257248)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgap29 Mutation:  30 strains or lines available
References
Original:  J:257248 Paul BJ, et al., ARHGAP29 Mutation Is Associated with Abnormal Oral Epithelial Adhesions. J Dent Res. 2017 Oct;96(11):1298-1305
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory