Lpltm1c(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Lpltm1c(KOMP)Wtsi |
Name: |
lipoprotein lipase; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6150636 |
Synonyms: |
Lplfl |
Gene: |
Lpl Location: Chr8:69333207-69359584 bp, + strand Genetic Position: Chr8, 33.88 cM
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Alliance: |
Lpltm1c(KOMP)Wtsi page
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IMPC: |
Lpl gene page |
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Mutant Cell Line: |
EPD0284_1_B10 |
Germline Transmission: |
Earliest citation of germline transmission:
J:258861
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Parent Cell Line: |
JM8A1.N3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 69346825 of Chromosome 8 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 69347653. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
(J:258861)
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Original: |
J:258861 An M, et al., ULK1 prevents cardiac dysfunction in obesity through autophagy-meditated regulation of lipid metabolism. Cardiovasc Res. 2017 Aug 1;113(10):1137-1147 |
All: |
1 reference(s) |
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