Mir23a^tm1Qjl
Targeted Allele Detail

Summary

• Symbol: Mir23a^tm1Qjl
• Name: microRNA 23a; targeted mutation 1, Qi-Jing Li
• MGI ID: MGI:6150441
• Synonyms: Mir23a^f
• Gene: Mir23a Location: Chr8:84935147-84935221 bp, + strand Genetic Position: Chr8, 40.58 cM
• Alliance: Mir23a^tm1Qjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258662
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of Mir23a and an FRT-flanked pgk-neo cassette, duplicate copy of Mir27a and loxP site were inserted downstream of Mir23a. The extra copy of Mir27a ensures that the full flanking region of the microRNA is maintained after Cre-mediated recombination. (J:258662)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir23a Mutation: 4 strains or lines available

References

• Original: J:258662 Zhang B, et al., MicroRNA-23a Curbs Necrosis during Early T Cell Activation by Enforcing Intracellular Reactive Oxygen Species Equilibrium. Immunity. 2016 Mar 15;44(3):568-581
• All: 1 reference(s)