Cav1^tm1.1Madp
Targeted Allele Detail

Summary

• Symbol: Cav1^tm1.1Madp
• Name: caveolin 1, caveolae protein; targeted mutation 1.1, Miguel Angel del Pozo
• MGI ID: MGI:6150433
• Synonyms: Y14F
• Gene: Cav1 Location: Chr6:17306387-17341323 bp, + strand Genetic Position: Chr6, 7.73 cM, cytoband A2
• Alliance: Cav1^tm1.1Madp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232807
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A Y14F mutation was introduced in exon 2 and a floxed neo cassette was inserted in intron 1 via homologous recombination. Cre-mediated recombination removed the neo cassette allowing expression of the mutant protein. (J:232807)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cav1 Mutation: 29 strains or lines available

References

• Original: J:232807 Schonle A, et al., Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells. Blood. 2016 Apr 14;127(15):1930-9
• All: 2 reference(s)