Rbl2^tm1.1Gfk
Targeted Allele Detail

Summary

• Symbol: Rbl2^tm1.1Gfk
• Name: RB transcriptional corepressor like 2; targeted mutation 1.1, Graham F Kay
• MGI ID: MGI:6149998
• Synonyms: p130^F2
• Gene: Rbl2 Location: Chr8:91796685-91850472 bp, + strand Genetic Position: Chr8, 44.25 cM
• Alliance: Rbl2^tm1.1Gfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243383
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by unidirectional loxP sites and a FRT-flanked PGK-neomycin selection cassette. Flp-mediated recombination removed the selection cassette. (J:243383)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbl2 Mutation: 52 strains or lines available

References

• Original: J:243383 Tonks ID, et al., Melanocyte transformation requires complete loss of all pocket protein function via a mechanism that mitigates the need for MAPK pathway activation. Oncogene. 2017 Jun 29;36(26):3789-3795
• All: 1 reference(s)