Sorcs2^tm1.1Blhe
Targeted Allele Detail

Summary

• Symbol: Sorcs2^tm1.1Blhe
• Name: sortilin-related VPS10 domain containing receptor 2; targeted mutation 1.1, Barbara L Hempstead
• MGI ID: MGI:6149994
• Gene: Sorcs2 Location: Chr5:36174524-36555483 bp, - strand Genetic Position: Chr5, 19.14 cM
• Alliance: Sorcs2^tm1.1Blhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244563
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 36386211 of Chromosome 5 upstream of the critical exon 2 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 2 at position 36386995. The critical exon 2 is thus flanked by loxP sites. Cre-mediated recombination without flp expression, produced a reporter knockout mouse. (J:244563)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sorcs2 Mutation: 70 strains or lines available

References

• Original: J:244563 Ma Q, et al., SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease. JCI Insight. 2017 May 04;2(9)
• All: 1 reference(s)