Ptpn22^em1Shrm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ptpn22^em1Shrm
• Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid); endonuclease-mediated mutation 1, Linda A Sherman
• MGI ID: MGI:6149963
• Synonyms: Ptpn22^R619W
• Gene: Ptpn22 Location: Chr3:103767111-103819563 bp, + strand Genetic Position: Chr3, 45.52 cM, cytoband F3
• Alliance: Ptpn22^em1Shrm page

Mutation origin

• Strain of Origin: NOD/ShiLtJ

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting generated a 4 nucleotide substitution in exon 14 that results in the amino acid substitution of tryptophan for arginine at position 619 (R619W). An additional silent mutation (CTC to CTT) was introduced at amino acid position 616. (J:246242)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptpn22 Mutation: 51 strains or lines available

References

• Original: J:246242 Lin X, et al., CRISPR-Cas9-Mediated Modification of the NOD Mouse Genome With Ptpn22R619W Mutation Increases Autoimmune Diabetes. Diabetes. 2016 Aug;65(8):2134-8
• All: 1 reference(s)