Hprt1^tm2(Zfy2)Jtu
Targeted Allele Detail

Summary

• Symbol: Hprt1^tm2(Zfy2)Jtu
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 2, James Turner
• MGI ID: MGI:6149947
• Synonyms: Z2, Z2-4
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^tm2(Zfy2)Jtu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171865
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Hprt1^tm2(Zfy2)Jtu expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Zfy2 (MGI:99213)

• Mutation details: The mouse BAC (CITB-5288D7) was used to make targeted transgenic mice. X-chromosome directed transgenesis was performed by cassette mediated exchange (CME). Other targeted transgenic founders and lines were made but did not transmit, express or male mice were sterile. (J:171865)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1280 strains or lines available

References

• Original: J:171865 Royo H, et al., Evidence that meiotic sex chromosome inactivation is essential for male fertility. Curr Biol. 2010 Dec 7;20(23):2117-23
• All: 7 reference(s)