Csnk2a1^tm1.1Mfla
Targeted Allele Detail

Summary

• Symbol: Csnk2a1^tm1.1Mfla
• Name: casein kinase 2, alpha 1 polypeptide; targeted mutation 1.1, Marc Flajolet
• MGI ID: MGI:6149735
• Synonyms: CK2alpha floxed
• Gene: Csnk2a1 Location: Chr2:152068759-152123772 bp, + strand Genetic Position: Chr2, 74.83 cM
• Alliance: Csnk2a1^tm1.1Mfla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:248415
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked with loxP sites and an adjacent frt-flanked neomycin selection cassette was removed via FLP-mediated recombination. Exon 2 contains the sequences encoding the adenosine triphosphate binding site; deletion results in a frameshift and the introduction of a premature stop codon. (J:248415)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csnk2a1 Mutation: 130 strains or lines available

References

• Original: J:248415 Rebholz H, et al., Selective knockout of the casein kinase 2 in d1 medium spiny neurons controls dopaminergic function. Biol Psychiatry. 2013 Jul 15;74(2):113-21
• All: 8 reference(s)