Prkd1^tm1.1Ouya
Targeted Allele Detail

Summary

• Symbol: Prkd1^tm1.1Ouya
• Name: protein kinase D1; targeted mutation 1.1, Kunfu Ouyang
• MGI ID: MGI:6149730
• Gene: Prkd1 Location: Chr12:50388014-50695881 bp, - strand Genetic Position: Chr12, 21.78 cM, cytoband C1
• Alliance: Prkd1^tm1.1Ouya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259563
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 971 bp fragment containing exon 14 was flanked by a loxP site and an FRT-flanked neomycin resistance cassette with an additional loxP site. Cre-mediated recombination removed the 971 bp and selection cassette. (J:259563)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkd1 Mutation: 58 strains or lines available

References

• Original: J:259563 Xiang SY, et al., PLCepsilon, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart. Sci Signal. 2013 Dec 17;6(306):ra108
• All: 1 reference(s)