Grn^tm1.1Blrl
Targeted Allele Detail

Summary

• Symbol: Grn^tm1.1Blrl
• Name: granulin; targeted mutation 1.1, Blair R Leavitt
• MGI ID: MGI:6149576
• Synonyms: Grn^flox
• Gene: Grn Location: Chr11:102321333-102327635 bp, + strand Genetic Position: Chr11, 66.29 cM
• Alliance: Grn^tm1.1Blrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211725
• Parent Cell Line: mEMS128 (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Parental line mouse Grn^tm1Blrl consisting of a loxP site inserted upstream of exon 3 and a cassette containing (5' to 3') a loxP site, FRT site, splice acceptor, IRES, beta-geo cassette, stop codon, polyadenylation sequence, and FRT site inserted downstream of exon 4 was crossed with Flp-deleter to remove the cassette leaving loxP flanked exons 3 and 4. (J:211725)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grn Mutation: 51 strains or lines available

References

• Original: J:211725 Petkau TL, et al., Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice. Neurobiol Aging. 2013 Nov;34(11):2548-50
• All: 2 reference(s)