Gt(ROSA)26Sor^{tm1.1(Ubc-Grn)Ite}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(Ubc-Grn)Ite}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Irmgard Tegeder
• MGI ID: MGI:6149573
• Synonyms: STOP-Grn^fl
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(Ubc-Grn)Ite} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258949
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(Ubc-Grn)Ite} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Grn (MGI:95832)

• Mutation details: A ubiquitin C promoter, a floxed stop cassette, mouse progranulin cDNA, and FRT flanked pgk-neo cassette were inserted via homologous recombination. Flp mediated recombination removed the neo cassette. (J:258949)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 945 strains or lines available

References

• Original: J:258949 Altmann C, et al., Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy. Neurobiol Dis. 2016 Dec;96:294-311
• All: 3 reference(s)