Cd3e^tm2.1Geno
Targeted Allele Detail

Summary

• Symbol: Cd3e^tm2.1Geno
• Name: CD3 antigen, epsilon polypeptide; targeted mutation 2.1, Genoway
• MGI ID: MGI:6149565
• Synonyms: C80G
• Gene: Cd3e Location: Chr9:44910038-44920925 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Cd3e^tm2.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259023
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A C80G mutation was created and an FRT flanked neo cassette was inserted in intron 6 via homologous recombination. Flp mediated recombination removed the neo cassette. This mutation is located in the extracellular domain of the protein and is designed to prevent outside-in transmission of conformational changes in the TCR. (J:259023)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd3e Mutation: 21 strains or lines available

References

• Original: J:259023 Blanco R, et al., Conformational changes in the T cell receptor differentially determine T cell subset development in mice. Sci Signal. 2014 Dec 2;7(354):ra115
• All: 1 reference(s)