Mtor^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Mtor^tm1.1Lex
• Name: mechanistic target of rapamycin kinase; targeted mutation 1.1, Lexicon Genetics
• MGI ID: MGI:6149564
• Synonyms: mTOR^kd
• Gene: Mtor Location: Chr4:148533068-148642140 bp, + strand Genetic Position: Chr4, 78.76 cM, cytoband E1
• Alliance: Mtor^tm1.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259585
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Insertion
• Mutation details: A D2338A was inserted in exon 50 and a floxed pgk-neo cassette was inserted in intron 50, 26 bp from the end of exon 50, via homologous recombination. Cre mediated recombination removed the neo cassette. (J:259585)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtor Mutation: 117 strains or lines available

References

• Original: J:259585 Shor B, et al., A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice. BMC Immunol. 2009 May 20;10:28
• All: 5 reference(s)