Dlg1^tm1.1Abrie
Targeted Allele Detail

Summary

• Symbol: Dlg1^tm1.1Abrie
• Name: discs large MAGUK scaffold protein 1; targeted mutation 1.1, Hugues Abriel
• MGI ID: MGI:6148208
• Synonyms: SAP97^fl
• Gene: Dlg1 Location: Chr16:31482261-31692174 bp, + strand Genetic Position: Chr16, 22.4 cM
• Alliance: Dlg1^tm1.1Abrie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237676
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/Ola

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: 3575 bp of the gene was flanked by loxP sites, including exons 1 to 3 and the promoter region of the gene. The 5 loxP site was inserted together with an FRT-flanked neomycin cassette 1014 bp upstream of exon 1, and the 3 loxP site was inserted 247 bp downstream of exon 3. The FRT-flanked neomycin selection cassette was removed via Flp-mediated recombination in mice. (J:237676)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dlg1 Mutation: 77 strains or lines available

References

• Original: J:237676 Gillet L, et al., Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current. Heart Rhythm. 2015 Jan;12(1):181-92
• All: 3 reference(s)