Sfn^tm1.2Hher
Targeted Allele Detail

Summary

• Symbol: Sfn^tm1.2Hher
• Name: stratifin; targeted mutation 1.2, Heiko Hermeking
• MGI ID: MGI:6148082
• Synonyms: Deleted 14-4-4sigma
• Gene: Sfn Location: Chr4:133327867-133329163 bp, - strand Genetic Position: Chr4, 66.25 cM, cytoband D3
• Alliance: Sfn^tm1.2Hher page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258722
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The entire gene was flanked by loxP sites. An frt-flanked neomycin selection cassette was removed via Flp-mediated recombination. Cre-mediated recombination deleted the gene in the germline. (J:258722)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sfn Mutation: 13 strains or lines available

References

• Original: J:258722 Winter M, et al., Deletion of 14-3-3sigma sensitizes mice to DMBA/TPA-induced papillomatosis. Oncotarget. 2016 Jul 26;7(30):46862-46870
• All: 2 reference(s)