Rela^tm1.1Ukl
Targeted Allele Detail

Summary

• Symbol: Rela^tm1.1Ukl
• Name: Rela proto-oncogene, NFKB subunit; targeted mutation 1.1, Ulf Klein
• MGI ID: MGI:6148061
• Gene: Rela Location: Chr19:5687511-5698158 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband B1-3
• Alliance: Rela^tm1.1Ukl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244578
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding a promoterless eGFP minigene, a loxP site and the PGKneo cassette was inserted upstream of exon 1 of the targeted gene; another loxP site followed by the PGK promoter was inserted downstream of exon 1. The entire targeted region was flanked by FRT sites. Cre-mediated recombination removes exon 1. (J:244578)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rela Mutation: 28 strains or lines available

References

• Original: J:244578 Badran YR, et al., Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration. J Exp Med. 2017 Jul 03;214(7):1937-1947
• All: 2 reference(s)