Pten^tm1.1Apri
Targeted Allele Detail

Summary

• Symbol: Pten^tm1.1Apri
• Name: phosphatase and tensin homolog; targeted mutation 1.1, Alice Prince
• MGI ID: MGI:6147869
• Synonyms: Ptenl^-
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm1.1Apri page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258142
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Insertion
• Mutation details: Two in-frame stop codon 32 and 30 codons were inserted upstream of the canonical start site and a floxed selection cassette were inserted. The selection cassette was then removed. This insertion blocks the expression of the long isoform. (J:258142)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 86 strains or lines available

References

• Original: J:258142 Riquelme SA, et al., Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity. Immunity. 2017 Dec 19;47(6):1169-1181.e7
• All: 2 reference(s)