Axl^tm1.1Cvro
Targeted Allele Detail

Summary

• Symbol: Axl^tm1.1Cvro
• Name: AXL receptor tyrosine kinase; targeted mutation 1.1, Carla V Rothlin
• MGI ID: MGI:6147861
• Synonyms: Axl^fl
• Gene: Axl Location: Chr7:25456698-25488130 bp, - strand Genetic Position: Chr7, 14.02 cM, cytoband A3-B1
• Alliance: Axl^tm1.1Cvro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234329
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 9. A FRT site, a loxP site, a neomycin resistance gene, a FRT site, and a third loxP site were inserted downstream of exon 10. Flp-mediated recombination removed the selection cassette, leaving exons 9-10 floxed. (J:234329)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Axl Mutation: 57 strains or lines available

References

• Original: J:234329 Schmid ET, et al., AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity. Elife. 2016;5:e12414
• All: 6 reference(s)