Ifih1^tm1Draw
Targeted Allele Detail

Summary

• Symbol: Ifih1^tm1Draw
• Name: interferon induced with helicase C domain 1; targeted mutation 1, David Rawlings
• MGI ID: MGI:6147852
• Synonyms: Ifih1^R
• Gene: Ifih1 Location: Chr2:62426142-62476599 bp, - strand Genetic Position: Chr2, 35.85 cM, cytoband C3
• Alliance: Ifih1^tm1Draw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257959
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: A loxP site was inserted at position 47703, a mutated exon 15 with an A947T mutation (GCA to ACA) was introduced and an FRT flanked neo cassette and loxP site were inserted at position 50710 via homologous recombination. This mutation mimics the human type 1 diabetes risk allele. (J:257959)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifih1 Mutation: 50 strains or lines available

References

• Original: J:257959 Gorman JA, et al., The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity. Nat Immunol. 2017 Jul;18(7):744-752
• All: 1 reference(s)